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J Nanosci Nanotechnol. 2013 Mar;13(3):1631-8.

Preparation and characterization of nano-hydroxyapatite nanomaterials for liver cancer cell treatment.

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1
Center for Nanoscience and Technology, K. S. Rangasamy College of Technology, Tiruchengode 637215, Tamil Nadu, India.

Abstract

Nano-hydroxyapatite was synthesized by means of the hydrothermal treatment. The effects of nano-hydroxyapatite material on the behaviour of G2 liver cancer cells were explored. About 50% of cell viability was lost in nHAp material treated cells at 200 degrees C @ 5 h, followed by -30% in nHAp treated cells at 100 degrees C @ 5 h. Compared with control, nHAp material treated cells at 200 degrees C @ 5 h showed 60% and nHAp material treated cells at 100 degrees C @ 5 h showed 15% morphological change. Moreover, 50% of cell death was observed at 24 h incubation with nHAp material treated at 200 degrees C @ 5 h cells and 56% cell death at 48 h incubation and hence alters and disturbs the growth of cancer cells. In contrast, the nHAp material treated at 100 degrees C @ 5 h protects the cells and could be used for liver cancer cell treatment.

PMID:
23755568
[Indexed for MEDLINE]
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