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PLoS One. 2013 Jun 5;8(6):e65798. doi: 10.1371/journal.pone.0065798. Print 2013.

Association between cannabinoid CB₁ receptor expression and Akt signalling in prostate cancer.

Author information

1
Pharmacology, Department of Pharmacology and Clinical Neuroscience, Umeå University, Umeå, Sweden.

Abstract

BACKGROUND:

In prostate cancer, tumour expression of cannabinoid CB₁ receptors is associated with a poor prognosis. One explanation for this association comes from experiments with transfected astrocytoma cells, where a high CB receptor expression recruits the Akt signalling survival pathway. In the present study, we have investigated the association between CB₁ receptor expression and the Akt pathway in a well-characterised prostate cancer tissue microarray.

METHODOLOGY/PRINCIPAL FINDINGS:

Phosphorylated Akt immunoreactivity (pAkt-IR) scores were available in the database. CB₁ receptor immunoreactivity (CB₁IR) was rescored from previously published data using the same scale as pAkt-IR. There was a highly significant correlation between CB₁IR and pAkt-IR. Further, cases with high expression levels of both biomarkers were much more likely to have a more severe form of the disease at diagnosis than those with low expression levels. The two biomarkers had additive effects, rather than an interaction, upon disease-specific survival.

CONCLUSIONS/SIGNIFICANCE:

The present study provides data that is consistent with the hypothesis that at a high CB₁ receptor expression, the Akt signalling pathway becomes operative.

PMID:
23755281
PMCID:
PMC3673925
DOI:
10.1371/journal.pone.0065798
[Indexed for MEDLINE]
Free PMC Article
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