Send to

Choose Destination
See comment in PubMed Commons below
Reprod Fertil Dev. 2014;26(6):778-86. doi: 10.1071/RD13092.

ART do not increase the risk of Y-chromosome microdeletion in 19 candidate genes at AZF regions.

Author information

Center for Reproductive Medicine, Department of Obstetrics and Gynaecology, Peking University Third Hospital, No. 49, Huayuan North Road, Haidian District, Beijing 100191, China.
Beijing Haidian Maternal and Child Health Hospital, No.33, Haidian South Road, Haidian District, Beijing 100080, China.


Y-chromosome microdeletions (YCMs) have been found at a much higher rate in infertile men than fertile controls. A specific deletion in the azoospermia factor locus (AZF) at Yq11 is significantly associated with male infertility. Whether assisted reproductive technology (ART) increases the risk of YCM in ART-derived offspring remains unclear. In this study the occurrence of YCM in 199 fathers and their 228 sons (Chinese, Han ethnicity), including 85 offspring conceived by IVF, 73 by intra-cytoplasmic sperm injection (ICSI) and 70 by natural conception, was investigated. Nineteen candidate genes related to YCM were analysed by multiplex ligation-dependent probe amplification. We identified one de novo YCM from 70 naturally-conceived offspring and none from 158 ART-conceived offspring and found no statistical significance between these two groups. There was no statistically-significant difference in the detection rate of the father's Y-chromosome microdeletion group: IVF 10.7% (8/75), ICSI 3.2% (2/63), natural conception 8.2% (5/61). These results suggest that ART does not increase the risk of YCM in male offspring.

[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for CSIRO
    Loading ...
    Support Center