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J Cell Biol. 2013 Jun 10;201(6):785-96. doi: 10.1083/jcb.201304054.

The incredible journey: From megakaryocyte development to platelet formation.

Author information

1
Hematology Division, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.

Abstract

Circulating blood platelets are specialized cells that prevent bleeding and minimize blood vessel injury. Large progenitor cells in the bone marrow called megakaryocytes (MKs) are the source of platelets. MKs release platelets through a series of fascinating cell biological events. During maturation, they become polyploid and accumulate massive amounts of protein and membrane. Then, in a cytoskeletal-driven process, they extend long branching processes, designated proplatelets, into sinusoidal blood vessels where they undergo fission to release platelets. Given the need for platelets in many pathological situations, understanding how this process occurs is an active area of research with important clinical applications.

PMID:
23751492
PMCID:
PMC3678154
DOI:
10.1083/jcb.201304054
[Indexed for MEDLINE]
Free PMC Article

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