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Curr Opin Immunol. 2013 Aug;25(4):428-35. doi: 10.1016/j.coi.2013.05.012. Epub 2013 Jun 8.

Humanized mice for the study of infectious diseases.

Author information

1
Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01655, United States.

Abstract

Many of the pathogens that cause human infectious diseases do not infect rodents or other mammalian species. Small animal models that allow studies of the pathogenesis of these agents and evaluation of drug efficacy are critical for identifying ways to prevent and treat human infectious diseases. Immunodeficient mice engrafted with functional human cells and tissues, termed 'humanized' mice, represent a critical pre-clinical bridge for in vivo studies of human pathogens. Recent advances in the development of humanized mice have allowed in vivo studies of multiple human infectious agents providing novel insights into their pathogenesis that was otherwise not possible.

PMID:
23751490
PMCID:
PMC3775881
DOI:
10.1016/j.coi.2013.05.012
[Indexed for MEDLINE]
Free PMC Article

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