Format

Send to

Choose Destination
See comment in PubMed Commons below
Clin Transl Sci. 2013 Jun;6(3):179-83. doi: 10.1111/cts.12041. Epub 2013 Apr 24.

Family history of dilated cardiomyopathy among patients with heart failure from the HF-ACTION genetic ancillary study.

Author information

1
University of Miami Miller School of Medicine, Miami, FL, USA.

Abstract

BACKGROUND:

The value of family history (FH) is well established, but its sensitivity to detect familial dilated cardiomyopathy (FDC) has been infrequently examined.

METHODS:

A genetic ancillary study was created as a component of the HF-ACTION trial, a multicenter, prospective, randomized clinical trial of exercise in patients with heart failure and an ejection fraction <35%. A FH-based study using a structured questionnaire mailed to all consenting individuals was incorporated into the genetic ancillary. FH responses were analyzed for dilated cardiomyopathy (DCM) in family members.

RESULTS:

Of the 741 individuals with data available, 358 (48.3%) had nonischemic and 383 (51.6%) had ischemic etiology, and of these 164 (45.8%) and 201 (52.4%), respectively, returned evaluable questionnaires. Of those with nonischemic etiology, 14/164 (8.5%) reported at least one first-degree family member with DCM or an enlarged heart; another 21/164 (12.8%) reported a FH of "cardiomyopathy," a less specific term to indicate DCM.

CONCLUSION:

At least 8.5% of patients with nonischemic etiology in the HF-ACTION genetic ancillary study provided FH indicating familial DCM, information important to inform further genetic analyses of this cohort and to plan other studies.

PMID:
23751021
PMCID:
PMC5350848
DOI:
10.1111/cts.12041
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wiley Icon for PubMed Central
    Loading ...
    Support Center