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Am J Respir Crit Care Med. 2013 Aug 1;188(3):309-18. doi: 10.1164/rccm.201302-0264OC.

Early-life air pollution and asthma risk in minority children. The GALA II and SAGE II studies.

Author information

1
Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA 94158, USA. katherine.nishimura@ucsf.edu

Abstract

RATIONALE:

Air pollution is a known asthma trigger and has been associated with short-term asthma symptoms, airway inflammation, decreased lung function, and reduced response to asthma rescue medications.

OBJECTIVES:

To assess a causal relationship between air pollution and childhood asthma using data that address temporality by estimating air pollution exposures before the development of asthma and to establish the generalizability of the association by studying diverse racial/ethnic populations in different geographic regions.

METHODS:

This study included Latino (n = 3,343) and African American (n = 977) participants with and without asthma from five urban regions in the mainland United States and Puerto Rico. Residential history and data from local ambient air monitoring stations were used to estimate average annual exposure to five air pollutants: ozone, nitrogen dioxide (NO₂), sulfur dioxide, particulate matter not greater than 10 μm in diameter, and particulate matter not greater than 2.5 μm in diameter. Within each region, we performed logistic regression to determine the relationship between early-life exposure to air pollutants and subsequent asthma diagnosis. A random-effects model was used to combine the region-specific effects and generate summary odds ratios for each pollutant.

MEASUREMENTS AND MAIN RESULTS:

After adjustment for confounders, a 5-ppb increase in average NO₂ during the first year of life was associated with an odds ratio of 1.17 for physician-diagnosed asthma (95% confidence interval, 1.04-1.31).

CONCLUSIONS:

Early-life NO₂ exposure is associated with childhood asthma in Latinos and African Americans. These results add to a growing body of evidence that traffic-related pollutants may be causally related to childhood asthma.

PMID:
23750510
PMCID:
PMC3778732
DOI:
10.1164/rccm.201302-0264OC
[Indexed for MEDLINE]
Free PMC Article

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