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Nat Sci Sleep. 2013 May 10;5:43-52. doi: 10.2147/NSS.S34841. Print 2013.

Hypertension and obstructive sleep apnea.

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Department of Respiratory and Sleep Medicine, Royal North Shore Hospital, Sydney, Australia ; National Health and Medical Research Council Center for Integrated Research and Understanding of Sleep, Woolcock Institute of Medical Research, University of Sydney, Sydney, Australia ; Discipline of Sleep Medicine, Sydney Medical School, University of Sydney, Sydney, Australia.


Obstructive sleep apnea (OSA) is increasingly being recognized as a major health burden with strong focus on the associated cardiovascular risk. Studies from the last two decades have provided strong evidence for a causal role of OSA in the development of systemic hypertension. The acute physiological changes that occur during apnea promote nocturnal hypertension and may lead to the development of sustained daytime hypertension via the pathways of sympathetic activation, inflammation, oxidative stress, and endothelial dysfunction. This review will focus on the acute hemodynamic disturbances and associated intermittent hypoxia that characterize OSA and the potential pathophysiological mechanisms responsible for the development of hypertension in OSA. In addition the epidemiology of OSA and hypertension, as well as the role of treatment of OSA, in improving blood pressure control will be examined.


ambulatory blood pressure; hypertension; intermittent hypoxia; obstructive sleep apnea; sympathetic activation

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