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Curr Protoc Bioinformatics. 2013 Jun;Chapter 3:Unit3.1. doi: 10.1002/0471250953.bi0301s42.

An introduction to sequence similarity ("homology") searching.

Author information

1
University of Virginia School of Medicine, Charlottesville, Virginia, USA.

Abstract

Sequence similarity searching, typically with BLAST, is the most widely used and most reliable strategy for characterizing newly determined sequences. Sequence similarity searches can identify "homologous" proteins or genes by detecting excess similarity- statistically significant similarity that reflects common ancestry. This unit provides an overview of the inference of homology from significant similarity, and introduces other units in this chapter that provide more details on effective strategies for identifying homologs.

PMID:
23749753
PMCID:
PMC3820096
DOI:
10.1002/0471250953.bi0301s42
[Indexed for MEDLINE]
Free PMC Article

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