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Int Orthop. 2013 Oct;37(10):2061-3. doi: 10.1007/s00264-013-1931-4. Epub 2013 Jun 9.

Association analysis of two candidate polymorphisms in the tumour necrosis factor-α gene with osteoarthritis in a Chinese population.

Author information

1
Department of Orthopaedic Surgery, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, No.164, Lanxi Road, Putuo District, 200062, Shanghai, China.

Abstract

PURPOSE:

The purpose of this study was to investigate the possible association between single nucleotide polymorphisms (SNPs) rs1800629 (TNF-α -308) and rs361525 (TNF-α -238) of the tumour necrosis factor (TNF)-α gene and susceptibility to osteoarthritis (OA) in the Han Chinese population.

METHODS:

The TNF-α -308 and -238 genotypes were determined by TaqMan assay in 200 OA cases and 305 controls. Odds ratios (ORs) for OA and 95% confidence intervals (CIs) from unconditional logistic regression models were used to evaluate relative risks.

RESULTS:

The frequencies of the allele 'A' of rs1800629 were 16% and 8.85% in OA cases and in controls, respectively, and thus the -308A allele had a 1.9612-fold (95% CI = 1.3323-2.8869, P < 0.001) increased risk for OA as compared to the -308G allele. However, no significant differences were found in the genotype and allele frequencies for rs361525 between OA and HC groups.

CONCLUSIONS:

In the Han Chinese population, the allele 'A' of TNF-α -308 may increase the risk for OA, whereas TNF-α -238 polymorphisms do not play a role in OA patients.

PMID:
23748461
PMCID:
PMC3779584
DOI:
10.1007/s00264-013-1931-4
[Indexed for MEDLINE]
Free PMC Article
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