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Nat Rev Microbiol. 2013 Jul;11(7):467-81. doi: 10.1038/nrmicro3047. Epub 2013 Jun 10.

Fortifying the barrier: the impact of lipid A remodelling on bacterial pathogenesis.

Author information

1
The Institute of Cellular and Molecular Biology, The University of Texas at Austin, 78712, USA.

Abstract

Gram-negative bacteria decorate their outermost surface structure, lipopolysaccharide, with elaborate chemical moieties, which effectively disguises them from immune surveillance and protects them from the onslaught of host defences. Many of these changes occur on the lipid A moiety of lipopolysaccharide, a component that is crucial for host recognition of Gram-negative infection. In this Review, we describe the regulatory mechanisms controlling lipid A modification and discuss the impact of modifications on pathogenesis, bacterial physiology and bacterial interactions with the host immune system.

PMID:
23748343
DOI:
10.1038/nrmicro3047
[Indexed for MEDLINE]

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