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Cell Metab. 2013 Jun 4;17(6):851-9. doi: 10.1016/j.cmet.2013.05.008.

Immunological goings-on in visceral adipose tissue.

Author information

1
Division of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA. cbdm@hms.harvard.edu

Abstract

Chronic, low-grade inflammation of visceral adipose tissue, and systemically, is a critical link between recent strikingly parallel rises in the incidence of obesity and type 2 diabetes. Macrophages have been recognized for some time to be critical participants in obesity-induced inflammation of adipose tissue. Of late, a score of other cell types of the innate and adaptive arms of the immune system have been suggested to play a positive or negative role in adipose tissue infiltrates. This piece reviews the existing data on these new participants; discusses experimental uncertainties, inconsistencies, and complexities; and puts forward a minimalist synthetic scheme.

PMID:
23747244
PMCID:
PMC4264591
DOI:
10.1016/j.cmet.2013.05.008
[Indexed for MEDLINE]
Free PMC Article

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