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Cell Metab. 2013 Jun 4;17(6):838-50. doi: 10.1016/j.cmet.2013.05.007.

Germline energetics, aging, and female infertility.

Author information

1
Vincent Center for Reproductive Biology, Massachusetts General Hospital, Boston, MA 02114, USA. jtilly@partners.org

Abstract

The role of metabolism in ovarian aging is poorly described, despite the fact that ovaries fail earlier than most other organs. Growing interest in ovarian function is being driven by recent evidence that mammalian females routinely generate new oocytes during adult life through the activity of germline stem cells. In this perspective, we overview the female reproductive system as a powerful and clinically relevant model to understand links between aging and metabolism, and we discuss new concepts for how oocytes and their precursor cells might be altered metabolically to sustain or increase ovarian function and fertility in women.

PMID:
23747243
PMCID:
PMC3756096
DOI:
10.1016/j.cmet.2013.05.007
[Indexed for MEDLINE]
Free PMC Article

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