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Cell Metab. 2013 Jun 4;17(6):814-5. doi: 10.1016/j.cmet.2013.05.016.

Agitation by suffocation: how hypoxia activates innate immunity via the Warburg effect.

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1
Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

Abstract

A hypoxic microenvironment can enhance the function of innate immune cells; however, the mechanisms remain unclear. Tannahill et al. (2013) find that in macrophages, the accumulation of succinate, an intermediate metabolite of the tricarboxylic acid cycle, stabilizes the transcription factor HIF-1α, leading to activation of the proinflammatory cytokine IL-1β.

PMID:
23747241
DOI:
10.1016/j.cmet.2013.05.016
[Indexed for MEDLINE]
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