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Leuk Res. 2013 Sep;37(9):998-1003. doi: 10.1016/j.leukres.2013.05.013. Epub 2013 Jun 6.

Geriatric assessment in older patients with acute myeloid leukemia: a retrospective study of associated treatment and outcomes.

Author information

1
College of Medicine, University of Cincinnati, Cincinnati, OH, United States.

Abstract

We explored whether geriatric assessment variables predicted mortality in addition to known prognostic factors in 101 patients aged ≥ 65 with newly diagnosed AML. Baseline comorbidity score (HR=1.92; 95%CI 1.18-3.11), difficulty with strenuous activity (HR=2.18; 95%CI 1.19-4.00), and pain (HR=2.17; 95%CI 1.19-3.97) were independent prognostic factors for greater risk of death in a multivariable model that included cytogenetic risk group. They remained independent predictors in the subset of patients with baseline ECOG PS 0-1. Our results support the use of geriatric assessment to better predict prognosis in older patients with AML, even among those with excellent functional status.

KEYWORDS:

Acute; Comorbidity; Geriatric assessment; Leukemia; Myeloid; Performance status; Prognosis

PMID:
23747082
PMCID:
PMC3735611
DOI:
10.1016/j.leukres.2013.05.013
[Indexed for MEDLINE]
Free PMC Article

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