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Curr Opin Genet Dev. 2013 Aug;23(4):438-44. doi: 10.1016/j.gde.2013.05.003. Epub 2013 Jun 5.

Planar cell polarity in vertebrate limb morphogenesis.

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1
National Human Genome Research Institute, Bethesda, MD 20892, United States.

Abstract

Studies of the vertebrate limb development have contributed significantly to understanding the fundamental mechanisms underlying growth, patterning, and morphogenesis of a complex multicellular organism. In the limb, well-defined signaling centers interact to coordinate limb growth and patterning along the three axes. Recent analyses of live imaging and mathematical modeling have provided evidence that polarized cell behaviors governed by morphogen gradients play an important role in shaping the limb bud. Furthermore, the Wnt/planar cell polarity (PCP) pathway that controls uniformly polarized cell behaviors in a field of cells has emerged to be critical for directional morphogenesis in the developing limb. Directional information coded in the morphogen gradient may be interpreted by responding cells through regulating the activities of PCP components in a Wnt morphogen dose-dependent manner.

PMID:
23747034
PMCID:
PMC3759593
DOI:
10.1016/j.gde.2013.05.003
[Indexed for MEDLINE]
Free PMC Article
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