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Curr Opin Immunol. 2013 Jun;25(3):321-8. doi: 10.1016/j.coi.2013.05.010. Epub 2013 Jun 6.

Transcriptional regulation of effector and memory CD8+ T cell fates.

Author information

1
Centre for Lung Infection, Papworth Hospital NHS Foundation Trust, Papworth Everard, Cambridge, United Kingdom. jedt2@cam.ac.uk

Abstract

Immunity to intracellular pathogens and cancer relies on the generation of robust CD8(+) T cell effector responses as well as the establishment of immunological memory. During a primary immune response CD8(+) T cells experience diverse extracellular environmental cues and cell-cell interactions that trigger downstream transcriptional programs ultimately guiding a CD8(+) T cell to undertake either an effector or a memory cell fate. Here, we discuss our current understanding of the signaling pathways and transcriptional networks that regulate effector and memory commitment in CD8(+) T lymphocytes.

PMID:
23747000
PMCID:
PMC3766771
DOI:
10.1016/j.coi.2013.05.010
[Indexed for MEDLINE]
Free PMC Article
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