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Phytomedicine. 2013 Jul 15;20(10):861-4. doi: 10.1016/j.phymed.2013.03.021. Epub 2013 Jun 7.

Double-blind placebo-controlled trial of hydroxytyrosol of Olea europaea on pain in gonarthrosis.

Author information

1
Faculty of Agriculture, Kinki University, 3327-204 Nakamachi, Nara 631-8505, Japan.

Abstract

Hydroxytyrosol is mainly found in olive leaves after hydrolysis of oleuropein and has anti-oxidant, anti-bacterial, and anti-inflammatory properties. The aim of this study was to investigate the effect of hydroxytyrosol for alleviating the pain in patients with gonarthrosis. We conducted a double-blind clinical trial in which hydroxytyrosol or placebo was administered to adult patients with gonarthrosis for 4 weeks. The group administered hydroxytyrosol showed significant improvement in the Japanese Orthopedic Association score (pain measurement index) and the visual analog scale score compared to the placebo group.

KEYWORDS:

Gonarthrosis; Hydroxytyrosol; Olea europaea; Olive; Pain

PMID:
23746949
DOI:
10.1016/j.phymed.2013.03.021
[Indexed for MEDLINE]

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