Format

Send to

Choose Destination
J Pediatr. 2013 Oct;163(4):1052-7.e2. doi: 10.1016/j.jpeds.2013.04.037. Epub 2013 Jun 6.

Health related quality of life in patients with biliary atresia surviving with their native liver.

Collaborators (187)

Schwarz K, Anders R, Colombani P, Karnsakul W, Osire SA, Pfeifer K, Wachter L, Whitington P, Alonso E, Bass L, Dunmars K, Jones D, Kelly S, Melin- Aldana H, Rizza D, Superina R, Tkaczyk K, Westfall E, Bezerra J, Bove K, Denlinger J, Heubi J, Jha P, LaGory D, Miethke A, Palermo J, Reed S, Setchell K, Stamper M, Tiao G, Sokol R, Dix M, Faut S, Hines J, Hite M, Jensen J, Karrer F, Lovell M, Mack C, Narkewicz M, Schardt T, Suchy F, Sundaram S, Van Hove J, Arnon R, Boyd M, Chu J, Cohen I, Iyer K, Magid M, Loomes K, Crisci T, Erlichman J, Flake A, Friedman J, Kusemiju O, Leonard L, Piccoli D, Rand E, Russo P, Spinner N, Wu E, Shneider B, Alissa F, Bernard B, Bowen A, Bukauskas K, Hoffmann P, Jaffe R, Lindblad D, Mazariegos G, Ortiz-Iguayo R, Perlmutter D, Scholz S, Sindhi R, Squires R Jr, Venkat V, Vockley J, Zecca D, Rosenthal P, Bull L, Fields S, Fleck S, Heyman M, Hirose S, Hoang V, Kim G, Langlois C, Pech J, Tejeda C, Roberts J, Wang L, Turmelle Y, Dillon P, Guelker S, Harris K, Heuckeroth R, Lowell J, Postma S, Rider J, Rudnick D, Stoll J, Weymann A, White F, Hertel P, Apted Z, Brandt M, Brown J, Carter B, Finegold M, Gibbs R, Harpavat S, Lynds J, McCartney T, Teckman J, Kociela V, Molleston J, Bozic M, Byam B, Haviland V, Klipsch A, Sawyers C, Subbarao G, Wegere J, West K, Murray K, Cooper K, Finn L, Healey P, Horslen S, Jacob S, Miethke A, Palermo J, Reed S, Setchell K, Stamper M, Ng V, Chiu A, Chung C, Day C, DeAngelis M, Fecteau A, Hunt K, Kamath B, Kovaleva T, Langer J, O'Connor C, Quammie C, Shakur L, VanRoestel K, Wang K, Cavallero J, Ford H, Goodhue C, Kerker N, Michail S, Hoang V, Kim G, Langlois C, Pech J, Roberts J, Wang L, Karpen S, Abramowsky C, de la Cruz-Tracy L, Francois-Marcello R, Gupta N, Rhodes J, Ricketts R, Romero R, Scott K, Sekar S, Shehata B, Turner-Green T, Vos M, Robuck P, Doo E, Hoofnagle J, Sherker A, Torrance R, Van Raaphorst R, Magee J, Jones K, Marchant B, Raghunathan T, Spino C, Ye W.

Author information

1
Departments of Gastroenterology, Hepatology, and Nutrition, Children's Hospital of Colorado, University of Colorado School of Medicine, Aurora, CO. Electronic address: shikha.sundaram@childrenscolorado.org.

Abstract

OBJECTIVES:

To quantify health related quality of life (HRQOL) of patients with biliary atresia with their native livers and compare them with healthy children and patients with biliary atresia post-liver transplant (LT) and to examine the relationship between HRQOL and medical variables.

STUDY DESIGN:

A cross-sectional HRQOL study of patients with biliary atresia with their native livers (ages 2-25 years) was conducted and compared with healthy and post-LT biliary atresia samples using Pediatric Quality of Life Inventory 4.0 child self and parent proxy reports, a validated measure of physical/psychosocial functioning.

RESULTS:

221 patients with biliary atresia with native livers (54% female, 67% white) were studied. Patient self and parent proxy reports showed significantly poorer HRQOL than healthy children across all domains (P < .001), particularly in emotional and psychosocial functioning. Child self and parent proxy HRQOL scores from patients with biliary atresia with their native livers and post-LT biliary atresia were similar across all domains (P = not significant). Child self and parent proxy reports showed moderate agreement across all scales, except social functioning (poor to fair agreement). On multivariate regression analysis, black race and elevated total bilirubin were associated with lower Total and Psychosocial HRQOL summary scores.

CONCLUSIONS:

HRQOL in patients with biliary atresia with their native livers is significantly poorer than healthy children and similar to children with post-LT biliary atresia. These findings identify significant opportunities to optimize the overall health of patients with biliary atresia.

KEYWORDS:

ALT; Alanine aminotransferase; GI; Gastrointestinal; HPE; HRQOL; Health related quality of life; Hepatic portoenterostomy; ICC; Intra-class correlation coefficient; LT; Liver transplant; Pediatric Quality of Life Inventory; PedsQL

PMID:
23746866
PMCID:
PMC4014354
DOI:
10.1016/j.jpeds.2013.04.037
[Indexed for MEDLINE]
Free PMC Article

Publication types, MeSH terms, Grant support

Publication types

MeSH terms

Grant support

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center