Send to

Choose Destination
Int J Pediatr Otorhinolaryngol. 2013 Aug;77(8):1244-7. doi: 10.1016/j.ijporl.2013.04.025. Epub 2013 Jun 6.

Exhaled biomarker pattern is altered in children with obstructive sleep apnoea syndrome.

Author information

Department of Oto-Rhino-Laryngology and Bronchology, Heim Pál Children's Hospital, 86 Üllői Str., 1089 Budapest, Hungary.



Obstructive sleep apnoea syndrome (OSAS) is a common disorder in children, which is associated with enhanced inflammatory status. Inflammation-associated changes could be monitored by the assessment of exhaled biomarker profile. This study aimed to compare the exhaled biomarker profile in children with OSAS and habitual snorers.


Eighteen children with OSAS (8 ± 2 years, mean ± SD) and ten non-OSAS subjects with habitual snoring (9 ± 2 years) were recruited. Exhaled breath was collected from the lower airways, processed using an electronic nose (E-nose) and analyzed off-line using principal component analysis, followed by discrimination analysis and logistic regression to build a receiver operating characteristic (ROC) curve.


Exhaled biomarker pattern of OSAS patients was discriminated from that of control subjects (p = 0.03, cross-validation accuracy: 64%), ROC curve analysis (area: 0.83) showed 78% sensitivity and 70% specificity.


The altered exhaled biomarker pattern in OSAS might reflect accelerated airway and/or systemic inflammation in diseased state. Breath pattern analysis by an E-nose can serve as a new tool to monitor inflammation in children with OSAS.


Breath analysis; Electronic nose; Exhaled volatile; Inflammation; Polysomnography; Sleep-disordered breathing

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center