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Int J Pediatr Otorhinolaryngol. 2013 Aug;77(8):1244-7. doi: 10.1016/j.ijporl.2013.04.025. Epub 2013 Jun 6.

Exhaled biomarker pattern is altered in children with obstructive sleep apnoea syndrome.

Author information

1
Department of Oto-Rhino-Laryngology and Bronchology, Heim Pál Children's Hospital, 86 Üllői Str., 1089 Budapest, Hungary. dr.benedek.palma@gmail.com

Abstract

OBJECTIVES:

Obstructive sleep apnoea syndrome (OSAS) is a common disorder in children, which is associated with enhanced inflammatory status. Inflammation-associated changes could be monitored by the assessment of exhaled biomarker profile. This study aimed to compare the exhaled biomarker profile in children with OSAS and habitual snorers.

METHODS:

Eighteen children with OSAS (8 ± 2 years, mean ± SD) and ten non-OSAS subjects with habitual snoring (9 ± 2 years) were recruited. Exhaled breath was collected from the lower airways, processed using an electronic nose (E-nose) and analyzed off-line using principal component analysis, followed by discrimination analysis and logistic regression to build a receiver operating characteristic (ROC) curve.

RESULTS:

Exhaled biomarker pattern of OSAS patients was discriminated from that of control subjects (p = 0.03, cross-validation accuracy: 64%), ROC curve analysis (area: 0.83) showed 78% sensitivity and 70% specificity.

CONCLUSIONS:

The altered exhaled biomarker pattern in OSAS might reflect accelerated airway and/or systemic inflammation in diseased state. Breath pattern analysis by an E-nose can serve as a new tool to monitor inflammation in children with OSAS.

KEYWORDS:

Breath analysis; Electronic nose; Exhaled volatile; Inflammation; Polysomnography; Sleep-disordered breathing

PMID:
23746417
DOI:
10.1016/j.ijporl.2013.04.025
[Indexed for MEDLINE]

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