Format

Send to

Choose Destination
See comment in PubMed Commons below
Curr Med Chem. 2013;20(27):3416-25.

Leptin in joint and bone diseases: new insights.

Author information

1
SERGAS, Research laboratory 9, Institute of Medical Research, Santiago University Clinical Hospital, Santiago de Compostela, 15706, Spain.

Abstract

Leptin is an adipokine with pleiotropic actions that regulates food intake, energy metabolism, inflammation and immunity, and also participates in the complex mechanism that regulates skeleton biology, both at bone and cartilage level. Leptin is increased in obesity and contributes to the "low-grade inflammatory state" of obese subjects causing a cluster of metabolic aberrations that affects joints and bone. In this review, we report the most recent research advances about the role of leptin in bone and cartilage function and its implication in inflammatory and degenerative joint diseases, such as osteoarthritis, rheumatoid arthritis and osteoporosis.

PMID:
23746275
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Bentham Science Publishers Ltd.
    Loading ...
    Support Center