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J Hypertens. 2013 Sep;31(9):1819-27. doi: 10.1097/HJH.0b013e328362b9d6.

Chronic resveratrol consumption improves brachial flow-mediated dilatation in healthy obese adults.

Author information

1
aNutritional Physiology Research Centre, Sansom Institute for Health Research bSchool of Psychology, Social Work and Social Policy, University of South Australia, Adelaide, South Australia, Australia cR&D Human Nutrition and Health, DSM Nutritional Products Ltd, Kaiseraugst, Switzerland dClinical Nutrition Research Centre, University of Newcastle, Callaghan, New South Wales, Australia.

Abstract

BACKGROUND:

We have previously demonstrated acute dose-dependent increases of flow-mediated dilatation (FMD) in the brachial artery after resveratrol consumption in mildly hypertensive, overweight/obese adults. Resveratrol supplementation has also been shown to increase cerebral blood flow acutely, without affecting cognition.

OBJECTIVES:

To evaluate the effects of chronic resveratrol supplementation on both FMD and cognitive performance.

METHOD:

Twenty-eight obese but otherwise healthy adults (BMI: 33.3 ± 0.6 kg/m) were randomized to take a single 75 mg capsule of trans-resveratrol (Resvida) or placebo daily for 6 weeks each in a double-blind crossover supplementation trial. Blood pressure, arterial compliance, FMD, and performance on the Stroop Color-Word Test were assessed at the end of each 6-week intervention period while fasted and at least 18 h after taking the last daily capsule. An additional capsule of the same supplement was then taken. FMD assessment was repeated 1 h later.

RESULTS:

Chronic resveratrol supplementation for 6 weeks was well tolerated and resulted in a 23% increase in FMD compared with placebo (P=0.021, paired t-test). The extent of increase correlated negatively with baseline FMD (r=-0.47, P=0.01). A single dose of resveratrol (75 mg) following chronic resveratrol supplementation resulted in a 35% greater acute FMD response than the equivalent placebo supplementation. These FMD improvements remained significant after adjusting for baseline FMD. Blood pressure, arterial compliance, and all components of the Stroop Color-Word Test were unaffected by chronic resveratrol supplementation.

CONCLUSION:

Daily resveratrol consumption was well tolerated and has the potential to maintain healthy circulatory function in obese adults.

PMID:
23743811
DOI:
10.1097/HJH.0b013e328362b9d6
[Indexed for MEDLINE]

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