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Int J Tuberc Lung Dis. 2013 Jul;17(7):961-8. doi: 10.5588/ijtld.12.0946.

Overall and cause-specific mortality among patients with tuberculosis and multidrug-resistant tuberculosis.

Author information

1
Department of Pulmonary Medicine, University of Tartu, Tartu, Estonia. kaivink@kodu.ee

Abstract

OBJECTIVE:

To assess overall and cause-specific mortality among patients with tuberculosis (TB) and multidrug-resistant tuberculosis (MDR-TB) in Estonia.

DESIGN:

A total of 2449 patients diagnosed with active respiratory TB from 1 January 2002 to 31 December 2009 were followed up retrospectively until 31 December 2011. To estimate the risk of death, standardised mortality ratios (SMR) and mortality rate ratios (RR) were calculated.

RESULTS:

The SMR for all-cause mortality among those diagnosed with TB was 5.30 (95%CI 4.85-5.75) in males and 10.00 (95%CI 8.25-11.74) in females. The relative risk of death from TB was higher among MDR-TB patients (adjusted RR in males 2.98, 95%CI 2.00-4.44, and in females 3.26, 95%CI 1.42-7.50) than among non-MDR-TB patients. Among the cohort of successfully treated patients, the SMR for all-cause mortality was 3.46 (95%CI 3.08-3.84) in males and 6.24 (95%CI 4.86-7.88) in females. Lower education level and foreign ethnicity contributed to the higher risk of mortality. Previous history of successfully treated MDR-TB did not increase the risk of death compared to successfully treated non-MDR-TB.

CONCLUSIONS:

Mortality among successfully treated TB and MDR-TB patients remained higher than among the general population. It was influenced by foreign ethnicity and lower education but, importantly, not by previous history of MDR-TB.

PMID:
23743316
DOI:
10.5588/ijtld.12.0946
[Indexed for MEDLINE]

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