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FEBS Lett. 2013 Jul 11;587(14):2247-53. doi: 10.1016/j.febslet.2013.05.054. Epub 2013 Jun 4.

MicroRNA-7 downregulates XIAP expression to suppress cell growth and promote apoptosis in cervical cancer cells.

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Tianjin Life Science Research Center and Basic Medical School, Tianjin Medical University, Tianjin, China.


Our study demonstrated the functions of microRNA-7 (miR-7) in cervical cancer. The overexpression of miR-7 in the cervical cancer cell lines HeLa and C-33A suppressed cell viability and promoted cell apoptosis, whereas the inhibition of miR-7 had opposite effects. Furthermore, an oncogene, X-linked inhibitor of apoptosis protein (XIAP), was identified as a new target of miR-7, and the ectopic expression of XIAP rescued the effects induced by miR-7 in HeLa and C-33A cells. These results indicate that miR-7 targeted and downregulated the oncogene XIAP to regulate the effect of miR-7 on apoptosis and malignant behaviors of HeLa and C-33A cells.

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