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Clin Biochem. 2013 Nov;46(16-17):1664-7. doi: 10.1016/j.clinbiochem.2013.05.066. Epub 2013 Jun 3.

Associations between genetic polymorphisms of paraoxonase genes and coronary artery disease in a Taiwanese population.

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1
Department of Pathology and Laboratory Medicine, Landseed Hospital, Taoyuan, Taiwan.

Abstract

OBJECTIVE:

We evaluated the relationship between polymorphisms of the paraoxonase (PON) gene and the risk of coronary artery disease (CAD) in Taiwanese patients.

METHODS:

Our sample set included 369 volunteers, classified into two groups: 162 healthy volunteers and 207 CAD patients aged 60.0 ± 9.7 and 64.3 ± 12.3 years, respectively. Polymorphisms of the PON1 and PON2 genes were determined using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) techniques.

RESULTS:

The results indicate that for the PON1 gene, the homozygous genotype RR was found significantly more often among the CAD group compared with the healthy group (OR=1.965, 95% CI=1.223-3.159, p=0.005). Furthermore, for the PON2 gene, the homozygous genotype CC was found significantly more often among the CAD group compared with the control group (OR=2.525, 95% CI=1.103-5.780, p=0.026).

CONCLUSIONS:

Individuals homozygous for the R allele of the PON1 gene and the C allele of the PON2 gene are more likely to have an increased risk of CAD.

KEYWORDS:

CAD; Gene polymorphisms; PON1; PON2; Paraoxonase

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