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Clin Biochem. 2013 Nov;46(16-17):1664-7. doi: 10.1016/j.clinbiochem.2013.05.066. Epub 2013 Jun 3.

Associations between genetic polymorphisms of paraoxonase genes and coronary artery disease in a Taiwanese population.

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Department of Pathology and Laboratory Medicine, Landseed Hospital, Taoyuan, Taiwan.



We evaluated the relationship between polymorphisms of the paraoxonase (PON) gene and the risk of coronary artery disease (CAD) in Taiwanese patients.


Our sample set included 369 volunteers, classified into two groups: 162 healthy volunteers and 207 CAD patients aged 60.0 ± 9.7 and 64.3 ± 12.3 years, respectively. Polymorphisms of the PON1 and PON2 genes were determined using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) techniques.


The results indicate that for the PON1 gene, the homozygous genotype RR was found significantly more often among the CAD group compared with the healthy group (OR=1.965, 95% CI=1.223-3.159, p=0.005). Furthermore, for the PON2 gene, the homozygous genotype CC was found significantly more often among the CAD group compared with the control group (OR=2.525, 95% CI=1.103-5.780, p=0.026).


Individuals homozygous for the R allele of the PON1 gene and the C allele of the PON2 gene are more likely to have an increased risk of CAD.


CAD; Gene polymorphisms; PON1; PON2; Paraoxonase

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