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Nanomedicine (Lond). 2014 Mar;9(3):441-56. doi: 10.2217/nnm.13.56. Epub 2013 Jun 7.

Mitochondria protection with ginkgolide B-loaded polymeric nanocapsules prevents diethylnitrosamine-induced hepatocarcinoma in rats.

Author information

1
Cell Biology & Physiology Division, Indian Institute of Chemical Biology, 4, Raja SC Mullick Road, Kolkata-700032, India.

Abstract

AIM:

Hepatocellular carcinoma (HCC) has no successful pharmacotherapeutic remedy. The aim of this study was to ascertain whether ginkgolide B (GB)-loaded polymeric nanocapsules can prevent diethylnitrosamine (DEN)-induced HCC in rats.

MATERIALS & METHODS:

GB was fabricated in two types of nanocapsules of which one was polyethylene glycol coated (N1GB) and the other was uncoated (N2GB). These nanocapsules were orally gavaged during DEN-induced HCC development in rats.

RESULTS:

Nanocapsulation of GB enabled aqueous suspension and slow time-dependent release of the compound. Anticarcinogenic potential of N2GB was reflected by its ability in the management of DEN-induced reactive oxygen species generation, mitochondrial dysfunction, p53, NF-κB, inducible nitric oxide synthase, COX-2 and VEGF expressions, and induction of apoptosis in cancer cells in the rat liver.

CONCLUSION:

Positive zeta-potential on N2GB surface might have offered higher hepatic accumulation of GB, especially at the electron-dense organelle mitochondria. Mitochondria protection against DEN-induced oxidative damage ensured HCC prevention.

PMID:
23742256
DOI:
10.2217/nnm.13.56
[Indexed for MEDLINE]

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