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PLoS One. 2013 May 31;8(5):e66282. doi: 10.1371/journal.pone.0066282. Print 2013.

DGCR8-mediated production of canonical microRNAs is critical for regulatory T cell function and stability.

Author information

1
Diabetes Center and the Department of Medicine, University of California San Francisco, San Francisco, California, United States of America.

Abstract

Regulatory T cells (Treg) are integral for immune homeostasis. Here we demonstrate that canonical microRNAs (miRNAs) are required for Treg function because mice with DGCR8-deficient Treg cells spontaneously develop a scurfy-like disease. Using genetic lineage marking we show that absence of miRNAs leads to reduced FoxP3 expression in Treg cells in vivo. In vitro culture of purified DGCR8-deficient Treg leads to a loss of FoxP3 expression. We conclude that canonical miRNAs are essential to maintain stable FoxP3 expression and Treg function. Thus, signals interfering with miRNA homeostasis might contribute to autoimmune diseases.

PMID:
23741528
PMCID:
PMC3669207
DOI:
10.1371/journal.pone.0066282
[Indexed for MEDLINE]
Free PMC Article
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