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J Virol. 2013 Aug;87(15):8808-12. doi: 10.1128/JVI.00718-13. Epub 2013 Jun 5.

MicroRNA 181 suppresses porcine reproductive and respiratory syndrome virus (PRRSV) infection by targeting PRRSV receptor CD163.

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1
State Key Laboratory of Agrobiotechnology, China Agricultural University, Beijing, China.

Abstract

We previously showed that microRNA 181 (miR-181) can inhibit PRRSV replication by directly targeting its genomic RNA. Here, we report that miR-181 can downregulate the PRRSV receptor CD163 in blood monocytes and porcine alveolar macrophages (PAMs) through targeting the 3' untranslated region (UTR) of CD163 mRNA. Downregulation of CD163 leads to the inhibition of PRRSV entry into PAMs and subsequently suppresses PRRSV infection. Our findings indicate that delivery of miR-181 can be used as antiviral therapy against PRRSV infection.

PMID:
23740977
PMCID:
PMC3719804
DOI:
10.1128/JVI.00718-13
[Indexed for MEDLINE]
Free PMC Article
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