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Contrast Media Mol Imaging. 2013 Sep-Oct;8(5):417-21. doi: 10.1002/cmmi.1538.

15N-permethylated amino acids as efficient probes for MRI-DNP applications.

Author information

1
Department of Chemistry and Center for Molecular Imaging, University of Turin, Via Nizza 52, 10125 Torino, Italy.

Abstract

The synthesis, NMR properties and preliminary polarization tests on protonated and perdeuterated forms of α-trimethylglutamine (NMe3Gln), α-trimethylglutamate (NMe3Glu) and ε-trimethyllysine (NMe3Lys) are reported. The (15)N-permethylated, perdeuterated amino acids display very long (15)N-T1 values, ranging between 190 and 330 s, are well polarized by the dynamic nuclear polarization (DNP) procedure, yielding good polarization levels (10%), and appear to be well tolerated by cells and mice. The obtained results make perdeuterated amino acids excellent candidates for innovative DNP (15)N-MRI applications such as perfusion or targeting studies.

PMID:
23740812
DOI:
10.1002/cmmi.1538
[Indexed for MEDLINE]

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