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Pediatr Obes. 2013 Oct;8(5):e50-3. doi: 10.1111/j.2047-6310.2013.00178.x. Epub 2013 Jun 6.

Replication of LIN28B SNP association with age of menarche in young Filipino women.

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1
Department of Genetics, University of North Carolina, Chapel Hill, NC, USA.

Abstract

BACKGROUND:

Age of menarche, or the timing of first menses in girls, is a physiological trait that shows substantial genetic heritability. Earlier age of menarche is associated with increased childhood adiposity and with adult risk of obesity and cardiovascular disease.

OBJECTIVES:

We sought to further characterize the single nucleotide polymorphism (SNP) rs7759938 from the menarche locus LIN28B in 827 young Filipino women from the Cebu Longitudinal Health and Nutrition Survey (CLHNS).

METHODS:

We tested rs7759938 for additive association with age of menarche and also tested whether childhood adiposity, as measured by body mass index (BMI) at age 8, mediated this relationship.

RESULTS:

We observed nominal association of rs7759938 with age of menarche (β = -0.118 years, 95% confidence interval = (-0.216, -0.020), P = 0.019) with an effect direction consistent with the previous report. We also observed suggestive evidence that the effect of the SNP on age of menarche was independent of childhood BMI.

CONCLUSIONS:

These data confirm the strongest gene reported in Europeans (LIN28B) as a contributor to age of menarche in an Asian population.

KEYWORDS:

Age of menarche; SNP association.; childhood adiposity; mediation analysis

PMID:
23740805
PMCID:
PMC3772980
DOI:
10.1111/j.2047-6310.2013.00178.x
[Indexed for MEDLINE]
Free PMC Article
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