Format

Send to

Choose Destination
Bioinformatics. 2013 Aug 1;29(15):1895-7. doi: 10.1093/bioinformatics/btt315. Epub 2013 Jun 5.

Triplex-Inspector: an analysis tool for triplex-mediated targeting of genomic loci.

Author information

1
Division of Genomics and Computational Biology, Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia.

Abstract

SUMMARY:

At the heart of many modern biotechnological and therapeutic applications lies the need to target specific genomic loci with pinpoint accuracy. Although landmark experiments demonstrate technological maturity in manufacturing and delivering genetic material, the genomic sequence analysis to find suitable targets lags behind. We provide a computational aid for the sophisticated design of sequence-specific ligands and selection of appropriate targets, taking gene location and genomic architecture into account.

AVAILABILITY:

Source code and binaries are downloadable from www.bioinformatics.org.au/triplexator/inspector.

CONTACT:

t.bailey@uq.edu.au

SUPPLEMENTARY INFORMATION:

Supplementary data are available at Bioinformatics online.

PMID:
23740745
PMCID:
PMC3712220
DOI:
10.1093/bioinformatics/btt315
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Silverchair Information Systems Icon for PubMed Central
Loading ...
Support Center