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EMBO Mol Med. 2013 Jul;5(7):973-83. doi: 10.1002/emmm.201100671. Epub 2013 Jun 6.

Balancing the fat: lipid droplets and human disease.

Author information

1
Department of Cell Biology, Yale School of Medicine, New Haven, CT, USA.

Abstract

Lipid droplets (LDs) are dynamic, cytosolic lipid-storage organelles found in nearly all cell types. Too many or too few LDs during excess or deficient fat storage lead to many different human diseases. Recent insights into LD biology and LD protein functions shed new light on mechanisms underlying those metabolic pathologies. These findings will likely provide opportunities for treatment of diseases associated with too much or too little fat.

KEYWORDS:

atherosclerosis; lipid droplet; lipodystrophy; metabolic syndrome; triglyceride storage

PMID:
23740690
PMCID:
PMC3721468
DOI:
10.1002/emmm.201100671
[Indexed for MEDLINE]
Free PMC Article
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