Format

Send to

Choose Destination
Ther Deliv. 2013 Jun;4(6):741-57. doi: 10.4155/tde.13.44.

Noncovalently associated cell-penetrating peptides for gene delivery applications.

Author information

1
Department of Pharmaceutical Chemistry, University of Kansas, Lawrence, KS, USA.

Erratum in

  • Ther Deliv. 2013 Nov;4(11):1470.

Abstract

The use of various cell-penetrating peptides (CPPs) to deliver genetic material for gene therapy applications has been a topic of interest for more than 20 years. The delivery of genetic material by using CPPs can be divided into two categories: covalently bound and electrostatically bound. Complexity of the synthesis procedure can be a significant barrier to translation when using a strategy requiring covalent binding of CPPs. In contrast, electrostatically complexing CPPs with genetic material or with a viral vector is relatively simple and has been demonstrated to improve gene delivery in both in vitro and in vivo studies. This review highlights gene therapy applications of complexes formed noncovalently between CPPs and genetic material or viruses.

PMID:
23738670
PMCID:
PMC4207642
DOI:
10.4155/tde.13.44
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Atypon Icon for PubMed Central
Loading ...
Support Center