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Muscles Ligaments Tendons J. 2012 Oct 16;2(3):239-42. Print 2012 Jul.

Mesenchymal stem cells, aging and regenerative medicine.

Author information

1
Laboratory of Experimental Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, USA.

Abstract

Tissue maintenance and regeneration is dependent on stem cells and increasing evidence has shown to decline with age. Stem cell based-aging is thought to influence therapeutic efficacy. Mesenchymal stromal cells (MSCs) are involved in tissue regeneration. Here, we discuss the effects of age-related changes on MSC properties considering their possible use in research or regenerative medicine.

KEYWORDS:

aging; mesenchymal stem cells (MSCs); regenerative medicine; stem cells

PMID:
23738303
PMCID:
PMC3666525

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