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ISRN Psychiatry. 2012 Jan 26;2012:482802. doi: 10.5402/2012/482802. Print 2012.

The Association between Alcohol Dependence and Depression before and after Treatment for Alcohol Dependence.

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Department of Psychiatry, University of Nairobi, P.O. Box 74846-00200, Nairobi, Kenya.


The presence of depression in alcohol-dependent persons is likely to influence treatment process and outcomes. Identification of depression is important though not every depressed alcohol-dependent person requires treatment with antidepressants. Understanding the association between depression and alcohol dependence is essential for proper management of alcohol dependence.


To determine the prevalence of depression among alcohol-dependent persons before and after alcohol detoxification and rehabilitation.


Clinical trial with pre-/postmeasurements.


The CIDI and WHO-ASSIST were administered to 188 alcohol-dependent persons at intake and after six months. A researcher-designed sociodemographic questionnaire was also administered at intake.


The prevalence of depression among alcohol-dependent persons is high (63.8%) with a significant association between depression and the mean AUDIT score. At posttest, depressed participants had a statistically significant craving for alcohol.


Alcohol dependence is associated with major depression.

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