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Case Rep Neurol Med. 2013;2013:590729. doi: 10.1155/2013/590729. Epub 2013 May 8.

A 17-year-old female with systemic lupus presents with complex movement disorder: possible relationship with antiribosomal p antibodies.

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1
Department of Neurology, Bezmialem Vakıf University, Adnan Menderes Bulvarı, Vatan Caddesi, 34093 Fatih İstanbul, İstanbul, Turkey.

Abstract

Complex movement disorder is a relatively rare presentation of neurolupus. Antiphospholipid antibodies are associated with movement disorders likely via aberrant neuronal stimulation. Antiribosomal P antibodies have been previously associated with neuropsychiatric disorders but their correlation with movement disorder was not previously established. Our case report involves a 17-year-old Caucasian female patient positive for only antiribosomal P antibody and lupus anticoagulant who presented with a sudden onset of complex movement disorder. After complete cessation of physical signs with olanzapine, anticardiolipin and anti- β 2 glycoprotein I antibodies became positive which indicates a likely discordance between movement disorder and antiphospholipid antibodies. This also indicates a potential causal role of antiribosomal P antibodies in inducing movement disorder.

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