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J Drug Deliv. 2013;2013:905091. doi: 10.1155/2013/905091. Epub 2013 May 2.

Nanoparticle albumin bound Paclitaxel in the treatment of human cancer: nanodelivery reaches prime-time?

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1
Medical Oncology Unit, Department of Experimental and Clinical Medicine, University "Magna Graecia" of Catanzaro and "Tommaso Campanella" Cancer Center, Campus Salvatore Venuta, Viale Europa, 88100 Catanzaro, Italy.

Abstract

Nanoparticle albumin bound paclitaxel (nab-paclitaxel) represents the first nanotechnology-based drug in cancer treatment. We discuss the development of this innovative compound and report the recent changing-practice results in breast and pancreatic cancer. A ground-breaking finding is the demonstration that nab-paclitaxel can not only enhance the activity and reduce the toxicity of chromophore-diluted compound, but also exert activity in diseases considered refractory to taxane-based treatment. This is the first clinical demonstration of major activity of nanotechnologically modified drugs in the treatment of human neoplasms.

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