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Cancer Biomark. 2013;13(1):29-35. doi: 10.3233/CBM-130322.

A meta-analysis of the association between glutathione S-transferase P1 gene polymorphism and the risk of adenocarcinomas of lung cancer.

Author information

1
Department of Cardio-Thoracic Surgery, People's Hospital of Beihai, Beihai, China.

Abstract

BACKGROUND:

Results of the published reports on the relationship between glutathione S-transferase P1 (GSTP1) gene polymorphism and the adenocarcinomas of lung cancer are still debated.

OBJECTIVE:

This meta-analysis was performed to evaluate the association between GSTP1 A/G gene polymorphism and the risk of adenocarcinomas of lung cancer.

METHODS:

The association investigations were identified from PubMed and Cochrane Library, and eligible studies were included and synthesized using meta-analysis method.

RESULTS:

16 reports were included into this meta-analysis for the association of GSTP1 A/G gene polymorphism and the risk of adenocarcinomas of lung cancer. The G allele and GG genotype were not associated with the susceptibility of risk of adenocarcinomas. Furthermore, in the sensitivity analysis, the results were similar with those from the non-sensitivity analysis.

CONCLUSIONS:

GSTP1 G allele or GG genotype is not a biomarker to be associated with the susceptibility of adenocarcinomas of lung cancer.

PMID:
23736019
DOI:
10.3233/CBM-130322
[Indexed for MEDLINE]

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