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FEBS Lett. 2013 Jul 11;587(14):2094-8. doi: 10.1016/j.febslet.2013.05.051. Epub 2013 Jun 2.

How crowded is the prokaryotic cytoplasm?

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1
Mallard Creek Polymers, Inc., 14700 Mallard Creek Road, Charlotte, NC 28262, USA. jspitz@mcpolymers.com

Abstract

We consider biomacromolecular crowding within the cytoplasm of prokaryotic cells as a two-phase system of 'supercrowded' cytogel and 'dilute' cytosol; we simplify and quantify this model for a coccoid cell over a wide range of biomacromolecular crowding. The key result shows that the supercrowded cytogel extends the vectorial character of the plasma membrane deeper into the cytoplasm by about 20-70 nm. We discuss useful physiological insights that this model gives into the functioning of a prokaryotic cell on the micrometer scale.

PMID:
23735698
DOI:
10.1016/j.febslet.2013.05.051
[Indexed for MEDLINE]
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