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Curr Opin Virol. 2013 Jun;3(3):285-95. doi: 10.1016/j.coviro.2013.05.011. Epub 2013 Jun 2.

Evasion of adaptive and innate immune response mechanisms by γ-herpesviruses.

Author information

1
Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA.

Abstract

γ-Herpesviral immune evasion mechanisms are optimized to support the acute, lytic and the longterm, latent phase of infection. During acute infection, specific immune modulatory proteins limit, but also exploit, the antiviral activities of cell intrinsic innate immune responses as well as those of innate and adaptive immune cells. During latent infection, a restricted gene expression program limits immune targeting and cis-acting mechanisms to reduce the antigen presentation as well as antigenicity of latency-associated proteins. Here, we will review recent progress in our understanding of γ-herpesviral immune evasion strategies.

PMID:
23735334
PMCID:
PMC4397892
DOI:
10.1016/j.coviro.2013.05.011
[Indexed for MEDLINE]
Free PMC Article

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