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J Biosci Bioeng. 2013 Nov;116(5):634-7. doi: 10.1016/j.jbiosc.2013.05.001. Epub 2013 Jun 2.

Intracellular observation of nanocarriers modified with a mitochondrial targeting signal peptide.

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1
Laboratory for Molecular Design of Pharmaceutics, Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-12, Nishi-6, Kita-ku, Sapporo 060-0812, Japan.

Abstract

This study focused on the intracellular observation of nanocarriers modified with a mitochondrial targeting signal peptide (MTS). The nanocarriers showed an efficient cellular uptake, and the MTS had a positive effect on their mitochondrial targeting. This is the first report of an intracellular observation of nanocarriers modified with MTS.

KEYWORDS:

MITO-Porter; Mitochondria; Mitochondrial drug delivery; Mitochondrial targeting signal peptide (MTS); Nanocarriers; Nanotechnology

PMID:
23735326
DOI:
10.1016/j.jbiosc.2013.05.001
[Indexed for MEDLINE]
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