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BMC Cancer. 2013 Jun 4;13:276. doi: 10.1186/1471-2407-13-276.

Infections in pediatric acute promyelocytic leukemia: from the Canadian infections in acute myeloid leukemia research group.

Abstract

BACKGROUND:

It is not known whether children with acute promyelocytic leukemia (APL) have an infection risk similar to non- APL acute myeloid leukemia. The objective was to describe infectious risk in children with newly diagnosed APL and to describe factors associated with these infections.

METHODS:

We conducted a retrospective, population-based cohort study that included children ≤ 18 years of age with de novo APL treated at 15 Canadian centers. Thirty-three children with APL were included; 78.8% were treated with APL -specific protocols.

RESULTS:

Bacterial sterile site infection occurred in 12 (36.4%) and fungal sterile site infection occurred in 2 (6.1%) children. Of the 127 chemotherapy courses, 101 (79.5%) were classified as intensive and among these, the proportion in which a sterile site microbiologically documented infection occurred was 14/101 (13.9%). There was one infection-related death.

CONCLUSIONS:

One third of children with APL experienced at least one sterile site bacterial infection throughout treatment and 14% of intensive chemotherapy courses were associated with a microbiologically documented sterile site infection. Infection rates in pediatric APL may be lower compared to non- APL acute myeloid leukemia although these children may still benefit from aggressive supportive care during intensive chemotherapy.

PMID:
23735034
PMCID:
PMC3679857
DOI:
10.1186/1471-2407-13-276
[Indexed for MEDLINE]
Free PMC Article
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