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Oncoimmunology. 2013 Apr 1;2(4):e23565.

Delineating the "galectin signature" of the tumor microenvironment.

Author information

1
Laboratorio de Glicómica Estructural y Funcional; IQUIBICEN-CONICET; Departamento de Química Biológica; Facultad de Ciencias Exactas y Naturales; Universidad de Buenos Aires; Buenos Aires, Argentina.

Abstract

Galectins, a family of glycan-binding proteins, can control tumor progression by promoting transformation, angiogenesis and immune escape. We identified a dynamically regulated 'galectin signature', which delineates the progression of prostate cancer, highlighting galectin-1 as an attractive target for anti-angiogenic therapy in advanced stages of the disease.

KEYWORDS:

angiogenesis; galectins; gene signature; metastasis; prostate cancer

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