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Chem Commun (Camb). 2013 Jul 18;49(56):6268-70. doi: 10.1039/c3cc42840k.

AlCl3-mediated hydroarylation-heteroarylation in a single pot: a direct access to densely functionalized olefins of pharmacological interest.

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1
Dr Reddy's Institute of Life Sciences, University of Hyderabad Campus, Gachibowli, Hyderabad 500 046, India.

Abstract

An unprecedented AlCl3-mediated method has been developed involving aromatic C-H bond addition to an alkyne and heteroarylation of an arene in a single pot leading to densely functionalized novel olefins, e.g. 2-(2,2-diarylvinyl)-3-arylquinoxalines, as potential inhibitors of sirtuins.

PMID:
23732749
DOI:
10.1039/c3cc42840k
[Indexed for MEDLINE]
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