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Gene. 2013 Sep 10;526(2):295-8. doi: 10.1016/j.gene.2013.05.026. Epub 2013 May 31.

CYP2C9 genotype and association with bone mineral density: a pilot study.

Author information

1
Division of Angiology, Department of Internal Medicine II, Medical University of Vienna, Vienna, Austria. sophie.ziegler@meduniwien.ac.at

Abstract

BACKGROUND:

In recent years reduced bone mineral density (BMD) and osteoporosis have become major public health problems. Single nucleotide polymorphisms (SNPs) in the cytochrome P450 2C9 (CYP2C9) gene influence the response to oral anticoagulant drugs, which are positively associated with the risk to develop osteoporosis. The aim of the present investigation was to clarify a potential role of CYP2C9 sequence variations and susceptibility to develop osteoporosis.

SUBJECTS AND METHODS:

Ninety two consecutive angiologic outpatients, mean age: 60.3±14.4, without secondary causes of bone loss were genotyped and classified as patients with normal BMD, osteopenia and osteoporosis according to WHO criteria by dual-energy X-ray absorptiometry at the lumbar spine and/or the femoral neck. Potential association between the CYP2C9 genotype and BMD was tested.

RESULTS:

59% of the patients (n=54) presented with reduced BMD and were compared to 38 age-matched persons with normal BMD. The genotype distribution showed 15% heterozygous for CYP2C9*2 p.Arg144Cys, 14% for CYP2C9*3 p.IIe359Leu, 2% for both polymorphisms, and 69% had wildtype genotypes. Patients with CYP2C9 mutations had significantly lower BMD values at the femoral neck and displayed a four-fold higher adjusted risk to suffer from reduced BMD than individuals with wildtype genotypes (p=0.02).

DISCUSSION:

Oral anticoagulant treatment is common in angiologic outpatients. The gene variants CYP2C9*2 and CYP2C9*3 have been shown to require lower maintenance doses of oral anticoagulant drugs. An association between oral anticoagulant drugs and the susceptibility to develop osteoporosis in relation to sequence variations in the CYP2C9 gene is suggested to be mediated via the glucocorticoid synthesis pathway.

CONCLUSION:

The CYP2C9*2/CYP2C9*3 variants were significantly associated with femoral BMD in a selected elderly Austrian population. These variants could contribute to the complex risk to develop osteoporosis.

KEYWORDS:

BMD; BMI; CYP2C9; CYP2C9 mutation; DEXA; Glucocorticoid synthesis; Oral anticoagulant treatment; Osteoporosis; SNP; body mass index; bone mineral density; cytochrome P450 2C9; dual-energy X-ray absorptiometry; single nucleotide polymorphism

PMID:
23732294
DOI:
10.1016/j.gene.2013.05.026
[Indexed for MEDLINE]

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