Format

Send to

Choose Destination
Endocrinol Nutr. 2013 Aug-Sep;60(7):379-85. doi: 10.1016/j.endonu.2013.02.005. Epub 2013 Jun 2.

[Estimated glucose disposal rate in patients under 18 years of age with type 1 diabetes mellitus and overweight or obesity].

[Article in Spanish]

Author information

1
Unidad de Endocrinología Pediátrica, Hospital General Universitario de Ciudad Real, Ciudad Real, España. palomo.enrique@gmail.com

Abstract

OBJECTIVE:

To assess the estimated glucose disposal rate (eGDR), insulin dose, and lipoprotein profile in children with type 1 diabetes mellitus (T1DM) and overweight or obesity as compared to children with T1DM and normal weight.

METHODS:

A total of 115 patients (aged 5-16 years) with T1DM on intensive insulin therapy were recruited. The following parameters were measured: weight, height, body mass index, waist and hip circumference, insulin dose, eGDR, glycosylated hemoglobin, blood pressure, and lipoprotein profile. Results were stratified by sex and age.

RESULTS:

No significant differences were found in eGDR between children with normal weight, overweight, and obesity. However, obese children older than 11 years had lower eGDR values (9.3±1.3 vs 10.1±0.8 mg kg(-1)min(-1); p<0.01). Insulin dose was higher in overweight and obese children, especially in IU/m2/day (37.7 vs 36.1 vs. 29.4 respectively; p<0.01). Obese children had higher low-density lipoprotein cholesterol levels than children with overweight and normal weight (106.5 vs 91.7 vs 91.5mg/dL respectively; p<0.01). No correlation was found between waist circumference and the different markers of insulin resistance.

CONCLUSIONS:

Values of eGDR values were lower in obese children with T1DM older than 11 years, and this may therefore be considered a marker of insulin resistance. Insulin dose was higher in diabetic patients with overweight or obesity, specially in IU/m2/day. Obese children with T1DM had a lipoprotein profile of cardiovascular risk.

KEYWORDS:

Diabetes mellitus; Insulin resistance; Metabolic syndrome; Overweight; Pediatrics; Pediatría; Resistencia a la insulina; Sobrepeso; Síndrome metabólico

PMID:
23731805
DOI:
10.1016/j.endonu.2013.02.005
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Ediciones Doyma, S.L.
Loading ...
Support Center