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Lung Cancer. 2013 Aug;81(2):308-10. doi: 10.1016/j.lungcan.2013.05.003. Epub 2013 May 31.

A case of lung adenocarcinoma harboring exon 19 EGFR deletion and EML4-ALK fusion gene.

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  • 1Department of Medical Oncology, Shanghai Pulmonary Hospital, Tongji University School of Medicine Tongji University Medical School Cancer Institute Tongji University, No 507 Zhengmin Road, Shanghai 200433, People's Republic of China.


We report a man with advanced adenocarcinoma who harboring exon 19 (E746-A750del) epidermal growth factor receptor (EGFR) deletion and echinoderm microtubule-associated protein like 4-anaplastic lymphoma kinase (EML4-ALK) gene translocation in the re-biospy specimen. The patient was treated with erlotinib with a stable disease but progressed slowly, while crizotinib showed a complete response.

Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.


Acquired resistance; Adenocarcinoma; EGFR mutation; EML4-ALK fusion; Lung

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