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Phytomedicine. 2013 Aug 15;20(11):980-4. doi: 10.1016/j.phymed.2013.03.023. Epub 2013 Jun 2.

Willow bark extract STW 33-I in the long-term treatment of outpatients with rheumatic pain mainly osteoarthritis or back pain.

Author information

1
Department of Natural Medicine, Charité University Medicine Berlin, Berlin, Germany. bernhard.uehleke@my-campus-berlin.com

Abstract

STUDY OBJECTIVE:

Efficacy and safety of willow bark extract for pain reduction in patients suffering from musculoskeletal disorders (MSD) has been shown in clinical short term trials. Therefore this observational study over 6 months should evaluate patterns of treatments like mono- or combinations therapy, dosage and safety during long-term treatment under pragmatic conditions with the aqueous willow bark extract STW 33-I, (Proaktiv(®); drug-extract-ratio 16-23:1).

PATIENTS AND METHODS:

The patients were treated with STW 33-I; comedication with other NSAIDs and opioids was allowed. An extensive case report form including pain questionnaires and patient diary was used for outcome evaluation.

RESULTS:

Four hundred and thirty-six patients with rheumatic pain mainly due to osteoarthritis (56.2%) and back pain (59.9%) were included. During the study the mean reductions from baseline value 58.4±22.6-31.8±22.5 after 24 weeks in the pain intensity scale (VAS 0-100mm) were significant even after 3 weeks with a reduction by 26 mm (45.6% of the baseline value) at the end of the study. The relative reductions of the weekly means of the daily patient self-rated scores of the pain (6-point Likert-scales) were between 33% and 44% of the baseline values during the course of the study. We present results of subgroups according their analgetic/antiphlogistic comedication. The distribution and specification of the main adverse events and the ratings of the treatment showed a good tolerability. No relevant drug interactions were reported.

CONCLUSION:

These data suggest that STW 33-I can be used as a basic treatment in the long-term therapy of painful musculoskeletal disorders and that it can be combined with NSAIDs and opioids if necessary.

KEYWORDS:

Back pain; Long-term-study; Osteoarthritis; Rheumatic pain; Willow bark

PMID:
23731658
DOI:
10.1016/j.phymed.2013.03.023
[Indexed for MEDLINE]
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