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Joint Bone Spine. 2014 Jan;81(1):37-40. doi: 10.1016/j.jbspin.2013.04.005. Epub 2013 Jun 2.

Predictors of response to anti-TNF therapy in RA patients with moderate or high DAS28 scores.

Author information

1
Rheumatology Unit, L.Sacco University Hospital of Milan, Milan, Italy. Electronic address: atzenifabiola@hotmail.com.
2
Rheumatology Unit, L.Sacco University Hospital of Milan, Milan, Italy.
3
Day Hospital of Rheumatology, G. Pini Orthopedic Institute, Chair of Rheumatology in Milan, Milan, Italy.
4
Rheumatology and Immunology Unit, Spedali Civili di Brescia, Brescia, Italy.
5
Chair of Rheumatology, IRCCS Policlinico S. Matteo, Pavia, Italy.
6
Internal Medicine, Ospedale di Saronno, A.O. Busto Arsizio, Saronno, Italy.

Abstract

OBJECTIVES:

To identify the clinical factors predicting a good clinical response to anti-TNF therapy in rheumatoid arthritis (RA) patients entered in the LORHEN registry after 5years of treatment with anti-TNF agents and divided into two groups on the basis of their baseline DAS28 scores (moderate>3.2-5.1 [MDA] and high>5.1 [HDA]).

METHODS:

Disease activity at baseline and after 12months was assessed using the DAS28, and response was evaluated using the EULAR improvement criteria.

RESULTS:

The study involved 1300 patients with established RA: 975 with HDA and 325 with MDA. After a mean 36-month, 29.6% of the patients had a DAS28 score of less or equal to 2.6 (HDA 25.8% vs. MDA 43.0%; P<0.001) and were considered to be in remission. A higher probability of a good EULAR response in patients with HDA was associated with male gender (F vs. M - OR 0.45, 95% CI 0.26-0.78; P: 0.004), lower age at the start of treatment (OR 0.98, 95% CI 0.96-0.99; P: 0.002), the absence of comorbidities (OR 0.18, 95% CI 0.06-0.52; P: 0.002) or no previous use of corticosteroids (OR 1.92, 95% CI 1.14-3.22; P: 0.015) and the use of adalimumab vs. infliximab (OR 2.21, 95% CI 1.37-3.57; P 0.001); in patients with MDA, the probability of a good EULAR response was associated with male gender (F vs. M - OR 0.39, 95% CI 0.17-0.90; P: 0.027).

CONCLUSIONS:

With the exception of male gender, the factors predicting a good EULAR response are different in patients with MDA and those with HDA.

KEYWORDS:

Anti-TNF; DAS28 scores; High and moderate disease activity; Predictive factors

PMID:
23731638
DOI:
10.1016/j.jbspin.2013.04.005
[Indexed for MEDLINE]
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