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Cogn Neurodyn. 2012 Jun;6(3):251-7. doi: 10.1007/s11571-011-9177-6. Epub 2011 Oct 22.

Synaptic consolidation: an approach to long-term learning.

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Université Paris Descartes, Paris, France.


Synaptic plasticity is thought to be the basis of learning and memory, but it is mostly studied on the timescale of mere minutes. This review discusses synaptic consolidation, a process that enables synapses to retain their strength for a much longer time (days to years), instead of returning to their original value. The process involves specific plasticity-related proteins, and depends on the dopamine D1/D5 receptors. Here, we review the research on synaptic consolidation, describing electrophysiology experiments, recent modeling work, as well as behavioral correlates.


Behavior; Electrophysiology; Model; Review; Synaptic consolidation; Synaptic plasticity; Synaptic tagging

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